Doctor Strange in the Multiverse of Madness Box Office Prediction

In what Hollywood is hoping looks more like a traditional summer season, it’s the MCU kicking it off with Doctor Strange in the Multiverse of Madness. The 28th feature in the biggest franchise of all is technically the follow-up to 2016’s Doctor Strange with Benedict Cumberbatch in the title role. It is, however, the character’s sixth appearance overall in the cinematic universe with the most recent being December’s massive Spider-Man: No Way Home. 

Speaking of Spidey, Sam Raimi, maker of Tobey Maguire’s 2002-2007 trilogy, directs (taking over from Scott Derrickson). Costars back in the mix are Elizabeth Olsen, Chiwetel Ejiofor, Benedict Wong, Michael Stuhlbarg, and Rachel McAdams. Newcomers to the MCU include Xochitl Gomez and Patrick Stewart (in an undisclosed role that could turn out to be quite familiar).

Madness has the big advantage of following a juggernaut in No Way Home. That has served as an advantage to other MCU properties. For instance, Captain Marvel in 2019 was the follow-up to Avengers: Endgame and it made $153 million out of the gate. That was slightly better than the Guardians of the Galaxy sequel from two years earlier. Assisting Multiverse is that the good Doctor had a sizable part in the previous Spidey adventure.

Five and a half years ago, the first Strange took in $85 million for its start with an eventual domestic haul of $232 million. In the MCU world, it’s way more normal for sequels to outdo their predecessors and that will certainly apply here. It should have no trouble achieving the largest premiere for 2022 – currently held by The Batman at $134 million.

No one is really thinking this will approach the $260 million weekend of No Way Home, but $200 million is definitely feasible. Underestimating the MCU is usually not wise so I’ll say it hits that mark. My projection would get it the 7th largest domestic debut of all time (right behind Jurassic World and just ahead of The Avengers).

Doctor Strange in the Multiverse of Madness opening weekend prediction: $208.5 million