If Seth MacFarlane lent his considerable talents to doing an audio commentary for an old western film, it would probably have the same effect as watching A Million Ways to Die in the West. Yet it would probably be funnier.

The “Family Guy” creator and maker of the wildly successful Ted in 2012 hits a sophomore slump here. West is set in the Old West of 1882 and MacFarlane’s Albert Stark is well aware of his surroundings. He is an aimless and wimpy sheepherder whose only ability seems to be noticing that the era he lives in is a real bummer. Outlaws kill for no reason and there is a myriad of diseases that can kill you, not to mention even the old timey cameras and blocks of ice that can humorously lead to violent ends. He meets his sarcastic counterpart in Anna (Charlize Theron), who also is highly cognizant of the miserable time period they’re stuck in. Unbeknownst to Albert, she is married to a notorious gunslinger Clinch (Liam Neeson) and trying to get away from him. Meanwhile, Albert is trying to get over his ex (Amanda Seyfried) who just left him for the proprietor (Neil Patrick Harris) of a successful mustache grooming shop titled The Mustachery.

The first hour of West presents us with the idea of its main characters aware of their bad luck in being stuck in the West and stretches the premise about as far as it can possibly go. The second half is at times more of a traditional Western, albeit one with an extremely generous heaping of bodily fluid gags and occasional drug humor. As you’d expect, no ethnic group of religion is spared from the constant quips, but they often feel like they’d be about the 12th most amusing line on a “Family Guy” episode.

Unlike his TV show and Ted, MacFarlane moves from voiceover work to being in front of the camera. Unfortunately, MacFarlane the screen presence is surprisingly dull much of the time. Neeson has little to work with in his menacing bad guy role, but it is odd nowadays to see the actor searching for a family member that actually left him intentionally. Part of the problem is that MacFarlane saves most of the funniest lines for himself and leaves little for Neeson, Theron, or Seyfried to work with. Harris has his moments and there is a subplot with Giovanni Ribisi and Sarah Silverman that has its share of genuine laughs.

By now we’ve come to expect plenty of non PC lines and gross out moments from MacFarlane. There’s much of that to be found here yet it doesn’t come close to the comedic heights of “Family Guy” at its best or Ted. The supporting cast doesn’t have enough to do and even a couple of well done cameos don’t help much. I will, however, admit that watching Ribisi repeat his dance moves from Ted had me laughing hard, even it was only for about five seconds.

MacFarlane and his cowriters Alec Sulkin and Wellesley Wild seem to believe the Albert character’s ongoing musings about the Old West and its nastiness are uproarious enough to make this worthwhile. Too often, those jokes play out like Albert’s firearm shooting abilities in the picture – some hits but plenty of misses.

** (out of four)